Extramural Grants:

 

Current Awards

 

      Principal Investigator

 

      National Cancer Institute                           R01 CA135297                                $1,557,249

      9/30/08-07/31/13                                              

      Hsp90 Regulates EphA2 Signaling and Cell Migration in Glioblastoma.

      Major Goal: Target one of the key oncogenic proteins involved in GBM progression as an approach to curtail cell migration         and to impact upon the invasiveness of the disease.

 

      Department of Defense                             PC110235                                         $553,124

      9/1/12-8/31/15                                       

      Extracellular Hsp90 as a novel epigenetic regulator of EMT and metastatic risk in prostate cancer

      Major Goal: Understand the mechanism by which EZH2 promotes eHsp90 mediated EMT events and tumor progression in         prostate cancer.

 

 

Completed Awards

 

      Principal Investigator

     

      National Cancer Institute                           K22 CA107212-01                              $420,498
      9/2005-8/2008                                      
      Hsp90-dependent regulation of HIF-1 alpha
      Major Goal: Elucidate the mechanisms for Hsp90 dependent regulation of HIF-1 in cancer.

      Commercial grant, Biogen Idec                                                                            $25,000
      2011 Major Goal: To define how Hsp90 modulated HIF transcriptional activity in renal cancer.

 

 

 

Intramural Grants:

 

Completed Awards 

     

      Principal Investigator

 

      American Cancer Society                           IRG-97-219-05                                     $19,500                                          11/01/05-10/30/06  

      Hsp90-dependent regulation of Eph tyrosine kinases

      Major Goal: Validate tumor-specific overexpression of Eph receptor proteins as Hsp90 targets susceptible to pharmacologic       inhibition.